![]() In this guide, we have put together a list of PDF editors (both free and proprietary) that you can leverage to modify your PDF documents. Occasionally, you might want to modify your PDF and maybe add text, images, fill forms, append a digital signature, and so on. You can seamlessly view a PDF document across multiple devices without visual alteration of its contents. So, you may not find it in your software center unless it supports Flatpak.The PDF file format is one of the most widely used document formats that is used to attach, transfer and download digital files thanks to its ease of use, portability, and ability to preserve all elements of a file. ![]() If you don’t know about Flatpak, you may want to follow our tutorial on using Flatpak in Linux. You will also find a Flatpak package on Flathub that you can install. rpm packages are available to download and you can get them from its official download page. If you want to get rid of the watermark, you can choose to purchase it. You can use it for free - but the unregistered version will have a watermark in your PDF files. With Master PDF Editor, you can do almost everything, ranging from editing a PDF file to edit scanned documents. Master PDF Editor is yet another proprietary application for editing PDF files. Supports digital signature and much more. ![]()
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![]() ![]() It is often easier to do a chore yourself than to wait for your child to do it. For example, this happens a lot with chores. There may be times when it will be easier to just do things yourself instead of sticking to the routine. It is important for the entire family to have a consistent routine. You will, of course, need to make changes to your routine occasionally, but the routine should be the rule and the change should be the exception. It keeps everyone on the same page and ensures that everyone is coordinated.Ī routine also ensures that you don’t forget to take care of anything. A routine lets everyone know what will happen and when it will happen. The Importance of a Daily Routine for KidsĪ daily routine is very helpful, both for kids and for their parents or caregivers. The school schedule template has only five days a week from Monday to Friday. Click on the black button above to open the weekly schedule maker for kids.The list currently contains the following activities (but you can edit them): school, play dates, homework, and chores. Go to the “Activities” tab and edit the list of activities that appear there. Spreadsheet How to change the list of activities? To change the color code, go to the “Activity” tab and change the list of activities. With this Excel schedule for kids, you can color-code different activities. Change the hourly schedule if you need to. Each subject is automatically color-coded. This weekly class schedule has a list of subjects that you can edit (in the tab “list of subjects”). You can also choose what day of the week you start from (i.e. The schedule maker gives you the option to choose any background and to choose the weekly schedule layout. We also have a weekly calendar or a daily planner template that is not specifically for kids. For example, you can record your family timetable schedule, and preschool schedule, or even create a weekly kids calendar template. You can use the blank schedule template for multiple purposes. You can change the background and the weekly schedule template for kids. This printable schedule for kids is available in many different formats and designs. The schedule won’t drive them around (unfortunately) but at least you will know where and when you are going. You have play dates to schedule, homework they must get done, and not to mention after-school activities you need to keep track of.Ī schedule for kids is a great way to get yourself and your kids organized. There is always so much going on with kids between school, after-school activities, and their social life. 1.3.1 The Importance of a Daily Routine for Kids Schedule for kids ![]() ![]() ![]() But I’d like to enjoy (this win) for a few minutes. “We’re going to have to be ready to play. “We all know they’re a good football team,” Franklin said of the unbeaten Buckeyes, who visit Happy Valley for a noon kickoff. Was it enough to get the Lions righted in time to give No. ![]() Kaliakmanis had little chance for success in his first career start and finished 9-for-22 for 175 yards, a touchdown and an interception.įor the Lions, rookie running back Nick Singleton helped put the game away with second-half touchdown runs of 16 and 30 yards, the latter coming after Penn State recovered an onside kick to snuff out the faintest hope of a comeback. It was an important development a week after the Wolverines humbled the Penn State defense to the tune of 418 yards on the ground, one of the worst totals in a game in program history. Ibrahim needed 30 carries to extend his impressive streak for a yards per carry of just 3.4 yards - down from a season average of 6.7. Ibrahim got his yards as he always does - the hard-charger finished over 100 for the 15th straight game and scored the Gophers’ first touchdown. That put all of the onus on star running back Mohamed Ibrahim and redshirt freshman quarterback Athan Kaliakmanis. And though he traveled with the Gophers to the game and was throwing in shorts early in warm-ups, he did not play.Īdd in that Minnesota was already missing top receiver Chris Autman-Bell - who had already been lost for the season with an injury - and the odds plummeted that the Gophers and former Lions offensive coordinator Kirk Ciarrocca would be able to knock off Penn State again. Morgan took a nasty hit to the head a week earlier against Illinois, necessitating a trip to the hospital. The Gophers (4-3, 1-3) played without their own sixth year signal-caller, Tanner Morgan, who had authored a 2019 upset that ended an unbeaten season for Penn State and Clifford that November. Minnesota had no such luck at quarterback. “I thought that, other than my interception, there weren’t really many flaws.”Ī major improvement, to say the least, and one that came a week after suffering an apparent shoulder injury that knocked him out of the Michigan game early.įranklin said he had a pretty good idea early in the week that Clifford would be able to play after examinations revealed “nothing structurally wrong, and it was just a pain management deal.” “We played probably our first complete game of the year, which was nice,” Clifford said. It was also Clifford’s fifth career game with at least four touchdown passes, another school record. The Tinsley score was his last throw of the night and was his 722nd career completion, breaking the all-time Penn State record set by his predecessor, Trace McSorley, who was in attendance. ![]() 16 Lions (6-1, 3-1 Big Ten), getting the tight ends involved in the passing game to open things up in a big way.Ĭlifford finished 23-for-31 for 295 yards and four touchdowns, connecting with Tyler Warren, Theo Johnson, Parker Washington and Mitchell Tinsley for scores. I’m real proud of him.”Īfter back-to-back rough outings against Northwestern and Michigan, Clifford responded for the No. “I think if you look around the country, there’s a lot of programs that would be super excited and happy about Sean Clifford being the quarterback, and what he was able to do tonight against one of the better defenses in the country. “No, I have no reactions to those types of things,” Lions coach James Franklin said before opening a defense of his quarterback. So when the Lions opened with no first downs on their first three drives - capped off with an overthrown deep ball by Sean Clifford that was intercepted - the 109,813 in attendance that came hoping for a party let them hear it. It hadn’t been the most jovial of weeks at Penn State, which had its 5-0 start come collapsing down last weekend with an embarrassing 41-17 loss at Michigan. And they delivered a White Out record in points, hammering Minnesota 45-17 on Saturday night. In danger of having their signature primetime crowd turn against them, the Nittany Lions recovered by the end of the first quarter. Loud ones, too, directed at Penn State’s offense. STATE COLLEGE - Yes, those were boos early on at Beaver Stadium. Penn State wide receiver Parker Washington, left, channeled another big play from White Outs past - Allen Robinson’s leaping grab against Michigan in 2013 - to haul in a 35-yard touchdown in the third quarter on Saturday. ![]() ![]() ![]() Simon is said to be struggling more with not being able to work rather than being told to throw out his “big boys toys”. The bike which Simon is understood to have shipped from the UK before falling off it of is described as a hyper-bicycle, which costs around £15,000 and can reach speeds of 60mph. ![]() “Thankfully he let go of the bike as he fell backwards and it didn’t land on him,” they continued to The Sun. “The power of the bike was unbelievable when he changed the setting up to the second one. Lauren Silverman (2013present engaged) Children: 1: Relatives: Nicholas Cowell (brother) Tony Cowell (half-brother) Simon Phillip Cowell (/. While stepping out for a stroll with his fiance Lauren Silverman on Wednesday, the music mogul. Get exclusive celebrity stories and fabulous photoshoots straight to your inbox with OK!'s daily newsletter. Simon Cowell has spoken out about his bike accident. Simon Cowell body transformation as his four stone weight loss likely to help his recovery from fall.Simon Cowell ‘takes a few steps’ despite being told he ‘won’t walk for weeks’ after breaking his back Celebrity Here’s Why Simon Cowell's Proposal To Lauren Silverman Was A Total Surprise By Madeleine Horton Published 'America's Got Talent' judge Simon Cowell finally popped the question to his long-term girlfriend Lauren Silverman.After he went home to his family, Simon explained, "He went 'Dad, you look like Iron Man.' And I went 'Yeah, I'm like Iron Man, yeah.Simon has been urged to "get rid" of his "big boy toys" after an accident on an electric bicycle (Image: Jeff Spicer/Getty Images) Read More Related Articles The surgery left him with metal rods and screws in his back. The Britain's Got Talent judge explained to Entertainment Tonight that when he arrived home following the incident, he was feeling incredibly "embarrassed." Things turn scandalous Even though she was. Did Lauren Silverman and Simon Cowell Have an Extramarital Affair. ![]() MORE: Simon Cowell, 63, shares unbelievable family update – how will son Eric react? Getty Images After two failed relationships, Simon went back to someone who made him feel at ease Lauren, a 44-year-old New York City socialite. Defensive driving can not only help prevent accidents, but it can also save lives. MORE: Simon Cowell finally shares thoughts on former BGT judge David Walliams controversy: 'Completely unacceptable' Simon and Lauren welcomed Eric on Valentine's Day in 2014, and the star revealed that his son came up with an incredible nickname for him following his bike accident last summer. I wasn't sure if I was going to be able to walk again, to ever play football with him." 'He hurt his back and was taken to the hospital. (X17) It seems the married woman allegedly carrying Simon Cowell’s baby is a bit of a scandal magnet. Simon Cowell proposed to his longtime love Cowell, 62, and his girlfriend Lauren Silverman are engaged, a source confirms to PEOPLE. ![]() (Error Code: 232011) Simon Cowell explained why he’s planning all of his wedding to. I couldn't do all the things I wanted to with him. In August 2020, he underwent surgery after he fell while testing out a bike in the courtyard of his Malibu, California, home. Simon Cowell soaking up the sun with Lauren Silverman in Saint Barths on January 4, 2012. Ap 3:48pm 0 seconds of 53 secondsVolume 0 00:00 00:53 This video file cannot be played. "I felt very depressed because I didn't know how to explain it to Eric. © Getty Images He has talked of his fiancé Lauren inspiring him to live a healthier lifestyle ![]() ![]() ![]() ![]() The place is then decorated with large Chinese screens, lanterns, and other cultural items. As Bee leaves the restaurant, she finds a penny on the floor, and Charlie tells her it is her lucky day. Aunt Bee, being a superstitious woman, considers the penny to be a sign, and decides to invest in the Chinese restaurant, against Andy’s advice.Ĭharlie Lee’s nephew, Jack, arrives in Mayberry to be the waiter in the new restaurant, and help Charlie and Bee carry out the renovations. Though Charlie would enjoy opening such a restaurant himself, there is a $400 hurdle to renovate the tavern and turn it into a Chinese restaurant, funding that Charlie does not possess. He explains that he began learning how to cook Chinese cuisine when he was 17 years old, and that he can prepare items like chop suey, chow mein, and egg rolls. Charlie then pivots to tell her that he thinks a Chinese restaurant in Mayberry would have been an excellent idea. Bee is disappointed, expressing that he is an excellent chef. With Henry not present, Aunt Bee speaks with chef Charlie Lee, who tells her that he plans to leave Mayberry and return to Pittsburgh. They also served hot dogs, pizza, meatballs, and their signature dish: barbecued ribs. The restaurant menu is mainly standard American, such as beef stew, roast beef, chicken fried steak, and ham with lima beans. Aunt Bee then stops by the Spare Ribs Tavern to speak to the owner, Henry. However, Gomer mentions that the restaurant had closed the day before. When Bee shows, she mentions that she might stop by the Spare Ribs Tavern and bring some home for dinner. At that time in the fictional town of Mayberry, there were few restaurants, most of which were diners, that provided basic American fare. As the episode begins, Andy and his friend, Gomer Pyle, are discussing what they would eat for lunch before Aunt Bee joins them. The episode, Aunt Bee’s Restaurant, aired on February 6, 1967. Fortunately, the episode presented a very positive image upon release, reaching households all across the country, and possibly helping to break erroneous preconceptions and prejudices against the Chinese. Thus, I was surprised to learn that one of the episodes was driven by a plot revolving around a Chinese restaurant. Today though, the series receives some criticism on the basis that there was very little in the way of diversity. The core of the story centered on Sheriff Andy Taylor, a widower who is raising his son, Opie, with the assistance of his Aunt Bee, all in the small town of Mayberry, North Carolina. The show pulled in high ratings throughout its run, and is commonly listed as one of the best series in television. The Andy Griffith Show, which aired from 1960-1968, is a beloved and iconic comedy series. ![]() ![]() ![]() You can see when and by whom each line of code was changed – inline in your editor. View and search Git log, view previous versions of a file, or compare branches, commits, and files across commits. If you are using Git for version control, this extension lets you explore the history of your project within VS Code. This extension integrates the JavaScript linter ESLint into VS Code. ![]() ✨ ESLintĬode linters analyze your code and find problems and errors. UPDATE: This extension is obviously no longer needed as VS Code now comes with support for. It allows you to define editor settings for a project so that, for example, a newline is inserted at the end of files automatically or that everyone indents their code with spaces, or tabs, or spaces, or tabs… editorconfig file has become a standard for many, especially when working together in teams. This integration for Visual Studio Code is an easy way to access documentation from VS Code. Dashĭash is an app that lets you read API documentation and code snippets, also offline. So useful once you get used to the many additional colors in your code. This extension colorizes matching brackets in the same color. Better Commentsīetter Comments will help you write, well, better comments by highlighting different types of comments, like alerts, questions, or TODOs, in different colors. This extension automatically adds HTML or XML closing tags so you don’t have to do it manually. If you have more to add, feel free to write me a message or email. So here’s the list of extensions I ended up installing, in alphabetical order. But which are the extensions one should install? I already had tried and installed quite a few extensions before but I also asked on Twitter to get other people’s opinions and maybe learn about a few extensions I hadn’t heard of before. One of the strengths of VS Code is the ecosystem of extensions that has grown quite substantially and many of the extensions can really take our coding experience one step further. As part of that, I also set up my development environment and my current editor of choice, Visual Studio Code. Consequently, I spent the past couple of days setting up my new Mac. Every time this had happened in the past, I took the opportunity to start from scratch and do a fresh install of all the software I in fact use and need. So after five years, it was time to get a new machine, after all. And then, the display of my MacBook Pro broke. ![]() ![]() Here's how to reach them:Įnter the question or issue you have and hit the search button. You can also ask for assistance in case you need help in installing it. You need to contact QuickBooks support directly so they can provide the right License and Product code of your QuickBooks version. If you have not previously registered your QuickBooks software, Intuits own knowledge base article on Missing or illegible installation numbers is no longer available online. ![]() If you have previously registered your QuickBooks software, you can get help finding your license number or key code from the License Look Up Tool. ProAdvisor members should go to the member support site for installation codes. If you purchased QuickBooks on CD, look for the a brightly coloured sticker on the original CD envelope. To find your license and product numbers.įor a downloaded product, look in the purchase confirmation email you received from Intuit. How to locate your license and product numbers It's part of the validation process which is important for any accounts software. In order to correctly install or reinstall any version of QuickBooks on your Dell system, you will need to have your license and product numbers ready as these will need to be entered during the install. Intuit QuickBooks License and Product numbers ![]() This article provides information on how to locate the license and products number from your version of QuickBooks so that you can install or reinstall it on your Dell PC. ![]() ![]() ![]() Census, Gaithersburg had a population of 69,657, making it the ninth-largest community in the state. Starting at 11:05 a.m., the shuttle will return to its normal schedule.Gaithersburg ( / ˈ ɡ eɪ θ ər z b ɜːr ɡ/ ( listen) GAY-thərz-burg), officially the City of Gaithersburg, is a city in Montgomery County, Maryland, United States. If there is a delayed opening, the first shuttle will leave Shady Grove one hour prior to opening time, and will leave the station every 15 minutes until 11:00 a.m. If bad weather causes a delayed opening or early closure of NIST, the shuttle schedule will be adjusted. ![]() The ride between NIST and the Shady Grove Metro Station takes approximately 15 minutes, depending on traffic conditions. The last shuttle leaves NIST at 6:05 p.m. The shuttle departs from the front of the NIST Administration Building at 5 and 35 minutes past the hour. The last NIST shuttle leaves Shady Grove Metro at 6:15 pm. The shuttle picks up at 15 and 45 minutes past the hour. If you are facing the front of the train, the east side is on your right, and is the side with the parking garages. Visitors using Metro can meet the NIST shuttle at Bus Bay C (the fourth bay on the row) on the east side of the Shady Grove Metro Station. The shuttle operates Monday through Friday, except on federal holidays, from 6:45 am to 6:15 pm. NIST provides shuttle service for official visitors and staff to and from the Shady Grove Metro Station. WMATA Trip Planner: This online tool allows for bus and rail planning with real-time departure and arrival information.Metrorail: The Shady Grove Metrorail station, on the Metro's Red Line, is about a 15-minute drive, taxi ride or shuttle ride from the NIST campus.RideOn bus: The Montgomery County bus system serves the NIST Gaithersburg campus, with the Route 54 bus stopping outside Building 101.To plan a route, please see the Montgomery County Bikeways Map.īikes are allowed on all RideOn buses and on most Metrorail cars. The City of Gaithersburg and surrounding Montgomery County offer a wide network of bike paths, many of which are separated from roadways. For specific guidelines on bicycle parking, please see Parking and Getting Around. NIST is accessible by bicycle and e-bike and provides free covered bike parking in multiple locations. Take the GW Parkway to 495 North toward MarylandĪt next stop light (Bureau Dr.), turn left Biking information ![]() Take 270 Local North toward Montrose RoadĪt the first light, turn right onto West Diamond Ave.įrom Ronald Reagan Washington National AirportĮxit National Airport heading north on the George Washington (GW) Parkway toward Maryland Take 495 West Exit #27-25 toward College Park/Silver Spring Take Exit #10 toward Clopper Road (MD 117) and Quince Orchard Rd (MD 124)Īt the first light, turn right onto West Diamond Ave.Īt next stop light (Bureau Dr.), turn leftįrom Baltimore Washington International Airport (BWI) Turn right at the first light onto NIST grounds.įrom Washington Dulles International Airport (IAD)įollow the Dulles Access Road to Bethesda/Baltimore entrance ramp to 495 124, Quince Orchard Road, turn left at the second light onto Route 117, West Diamond Avenue. Bear right at the light onto Route 124 West, Quince Orchard Road. At the next light, turn left onto the NIST grounds.įrom southbound I-270: Take Exit 11, Route 124, Montgomery Village Avenue/Quince Orchard Road. Bear right at the first light onto Clopper Road/West Diamond Avenue. See the Parking and Getting Around page for details.įrom northbound I-270: Take Exit 10, Route 117 West, Clopper Road. Consider taking public transportation as an alternative. When driving to NIST, plan some extra time to get through the security checkpoints at the visitor entrances to campus. Shuttle from Shady Grove Metro Driving directions ![]() ![]() ![]() 4Easysoft Total Video Converter 4Easysoft Total Video Converter is one of the versatile iPod video Converter you can find on the Windows and Mac market, which supports 600+ formats, including the MP3, WAV, MP4, and AIFF for iPod. If you are looking for a perfect and free iPhone/iPad/iPod manager and iTunes Extractor on Mac, Syncios for Mac will be the best choice. Top 8 iPod Video Converters for You Desktop & Online 1. It enables you toone-click backup your iDevice to Mac or restore everything on iPhone/iPad/iPod by one mouse click. This would help you get files backup to Mac if your iDevices got lost or damaged. With Syncios for Mac, you can also easily extract contacts, photos, call history, notes and messages from iTunes bacup files to Mac. Such as saving text messages with attachments to Mac. You can also manage and backup notes, bookmarks and messages on iOS devices. What's more, you can backup contacts to VCF format from iPhone to Mac, import contacts to iPhone, or directly add or edit contacts. Syncios iPod Audio Converter is a universal iPod Audio file converter, which supports converting popular audio formats to another that supported by iPod. Add files from Mac to iOS devices, back up iOS devices contents to Mac, select and delete unwanted files and move media files to suitable playlist will not be a hard task again. You are allowed to build new albums and then import photos from iMac and MacBook to iPad. If you are looking for free wallpaper and ringtones, Syncios iOS Manager would be the best choice. There are also free handy build-in tools in Syncios iOS Transfer: free Audio Converter, free Video Converter, free Rintone Maker, free iTunes Backup Management and more functions. You can also import video files: movies, TV shows, music videos, etc from Mac to iDevices. Transfer files from your PC to phone or tablet will be also available. You can create new playlist to iPhone, iPod touch and iPad on Mac and then import audio files: music, Podcasts, iTunes U, and audiobook. ![]() Transfer files from Mac to iOS devices will be also available. Simply connect your iDevices to Mac, select the files and click Export button. You can also backup all files, including music, videos, photos, contacts, notes, apps and more from iPhone, iPod touch or iPad to Mac's hard drive, such as iMac, MacBook Pro or MacBook Air. With Syncios for Mac, you can copy iPhone/iPod/iPad music and playlists, videos, Podcasts to your iTunes Library on Mac. Download SynciOS - Syncios is free but powerful iPad/iPhone/iPod to PC transfer which offers you ultimate solution for transferring media contents between iOS devices and PC. If you don't want to use iTunes for data synchronization between iPhone/iPad/iPod and mac, Syncios for Mac would be the best and free choice, which would help you manage all files on your Apple devices. If there is a problem playing the file on a device, then use Aimersoft DRM Media Converter for Windows to remove DRM protection.Syncios for Mac is free and professional iPhone/iPod/iPad/Android Manager tool for Mac users. On Windows, several other options are available, such as MediaMonkey, Winamp, and Helium Music Manager. Please note that iTunes must already be installed on your computer for running this free Syncios iPod Classic Transfer correctly. Download and install Syncios iPod Classic Transfer on your computer. The cross-platform option, which includes all popular operating systems and mobile, is VLC media player. Step 1: Download and install the free Syncios iPod Classic Transfer. Since M4P files protect iTunes files, naturally the default program for opening them is iTunes. The specific name of Apple’s DRM protection is “ FairPlay,” which is precisely what protects the content in M4P files. Note: The trial version of Sidify Music Converter enables us to convert the first 3-minute audio from. Massive free resources: videos, wallpapers, ringtones. Essentially, Apple uses this file format to prevent unauthorized use of the music files that are available for download from the iTunes Music Store. How do i download a playlist to my ipod shuffle. Download videos from 100+ video sharing sites up to 4K HD video quality and transfer to iPad/iPhone/iPod. Apple iTunes Music Store (M4P) file is an Advanced Audio Coding (AAC) file that protects its content with Digital Rights Management (DRM) technology. ![]() ![]() ![]() Therefore, we conducted a systematic review and meta-analysis to evaluate the efficacy and safety including ETHOS trial. Recently, a large new ETHOS trial has been performed to clarify the ICS add-on effects. ![]() Therefore, the evidence from these systematic reviews is mainly from one large randomized controlled trial (RCT), the IMPACT study which was performed for 52 weeks using a single inhaler device, and it remains unclear whether the ICS add-on treatment is beneficial or not. However, the included trials contain several biases, such as not using a single inhalation device, using different LABA between the comparison groups or a short evaluation duration of only 24 weeks. Until now, five systematic reviews have been performed to evaluate the efficacy and safety of ICS add-on to LAMA/LABA treatment. Therefore, a decision for the long-term use of ICS should be based on the total benefit for such patients. However, in severe COPD patients, the additional treatment of ICS could increase the incidence of pneumonia. Recently, a reduction of the mortality has also been shown by this treatment. If the patients have severe symptoms and a history of exacerbations, the addition of inhaled corticosteroid (ICS) to long-acting muscarinic antagonist (LAMA) and long-acting beta-agonist (LABA) combination therapy has been recommended because it lowers the incidence of exacerbations. To reduce the symptoms and the exacerbation, single or dual inhaled bronchodilators are recommended for the treatment depending on the severity. The symptoms include dyspnea, cough and sputum production and worsen during exacerbations of COPD, which are associated with accelerated mortality. However, these results should be only applied to patients with symptomatic moderate to severe COPD and a history of exacerbations.Ĭlinical Trial Registration: PROSPERO CRD42020191978.Ĭhronic obstructive pulmonary disease (COPD) is the third leading cause of death in the world. In addition, triple therapy is also superior to LABA/LAMA due to the lower mortality and better dyspnea score. Triple therapy causes a higher incidence of pneumonia but is a more preferable treatment than LAMA/LABA due to the lower incidence of exacerbations, higher trough FEV 1 and better QOL score. ![]() Concerning the trough FEV 1, QOL score and dyspnea score in both protocols, the differences were less than the minimal clinically important difference. In the ICS-withdrawal protocol including 2 RCTs, triple therapy also showed a significantly better QOL score and higher trough FEV 1 than LAMA/LABA. However, triple therapy showed a significantly higher incidence of pneumonia (odds ratio 1.52, 95% CI 1.16–2.00). In addition, triple therapy significantly improved the dyspnea score (mean difference 0.33, 95% CI 0.18–0.48) and mortality (odds ratio 0.66, 95% CI 0.50–0.87). ICS/LAMA/LABA treatment (triple therapy) significantly decreased the incidence of exacerbations (rate ratio 0.73, 95% CI 0.64–0.83) and improved the QOL score and trough FEV 1 compared to LAMA/LABA. We identified a total of 6 RCTs in ICS add-on protocol (N = 13,579). We searched relevant randomized control trials (RCTs) and analyzed the exacerbations, quality of life (QOL), dyspnea symptom, lung function and adverse events including pneumonia and mortality, as the outcomes of interest. However, the evidence is mainly based on one large randomized controlled trial IMPACT study, and it remains unclear whether the ICS add-on treatment is beneficial or not. ![]() In addition, a reducing effect on mortality has been shown by this treatment. Recently, the addition of inhaled corticosteroid (ICS) to long-acting muscarinic antagonist (LAMA) and long-acting beta-agonist (LABA) combination therapy has been recommended for patients with COPD who have severe symptoms and a history of exacerbations because it reduces the exacerbations. ![]() |
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